Syria Is First Time Use For F-22's

 internal Weapons Bay of a F-22 raptor, while demonstrating at a Blue Angels Airshow in San Antonio, Texas (Photo credit: Wikipedia)

 "...The first actual-combat deployment of the fifth-generation, multi-role fighter was likely selected to counter Syria’s advanced air defense system, which would require a high degree of altitude and maneuverability to execute strikes from a safe and precise distance..." [RED CLIX]